Pseudoautosomal Region 1 Length Polymorphism in the Human Population
نویسندگان
چکیده
منابع مشابه
Pseudoautosomal Region 1 Length Polymorphism in the Human Population
The human sex chromosomes differ in sequence, except for the pseudoautosomal regions (PAR) at the terminus of the short and the long arms, denoted as PAR1 and PAR2. The boundary between PAR1 and the unique X and Y sequences was established during the divergence of the great apes. During a copy number variation screen, we noted a paternally inherited chromosome X duplication in 15 independent fa...
متن کاملCorrection: Pseudoautosomal Region 1 Length Polymorphism in the Human Population
Two errors are included in the published manuscript. In the abstract the sentence ‘‘Subsequent genomic analysis demonstrated that an insertional translocation of X chromosomal sequence into theMa Y chromosome generates an extended PAR.’’ Should read ‘‘Subsequent genomic analysis demonstrated that an insertional translocation of X chromosomal sequence into the Y chromosome generates an extended ...
متن کاملRecombination in the Human Pseudoautosomal Region PAR1
The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossove...
متن کاملThe Eutherian Pseudoautosomal Region.
The pseudoautosomal region (PAR) is a unique segment of sequence homology between differentiated sex chromosomes where recombination occurs during meiosis. Molecular and functional properties of the PAR are distinctive from the autosomes and the remaining regions of the sex chromosomes. These include a higher rate of recombination than genome average, bias towards GC-substitutions and increased...
متن کاملRecombination in the human pseudoautosomal region PAR1 Text S1
2 Measuring PRDM9 binding in PAR1 in a human cell line 3 2.1 Generating a YFP-PRDM9 construct . . . . . . . . . . . . . . . . . . . . . . 3 2.2 Transfection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 ChIP-seq . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.4 Sequence filtering and processing . . . . . . . . . . . . . . . . . . . ....
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2014
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1004578